The jnk.vs.3 experiment is a virtual screening experiment designed specifically for computationally intensive methods. For this experiment, participants should use the co-crystals from the first two experiments (jnk.vs.1 and jnk.vs.2). For this experiment, a small subset of less than 500 ligands will be provided to participants. While the statistical significance for this portion of the virtual screening will be much lower than for the first two virtual screening experiments, we felt it would be valuable to evaluate more rigorous methods such as MMPB/SA in this setting.